I tend to think they are major cities.
In that case... Denton is not a major city and we shouldn't be grouped in that. Denton is to Dallas what Norman is to Oklahoma City. Oklahoma City is a major city. U. of Colorado is to Denver what UNT is to Dallas.
LSU in Baton Rouge. Baton Rouge is a major city. Miami U has been a traditional powerhouse. Tempe, Lexington, Pittsburgh are all major cities. Columbia South Carolina and metro area. Knoxville, TN and metro. U. Of Arizona in Tuscon. Washington in Seattle.
In basketball practically the entire Big East is in a big city.. dupaul, butler, creighton, georgetown, marquette, St Johns, Xavier.
Nebraska in Omaha, Rutgers had sniffed success. Syracuse, Duke. NCS in Raliegh has done good things. All i would consider big cities.
Many of these are of the 100 largest cities in the country.